Vitamin C provides numerous health benefits, including immune system support, antioxidant effects, and skin health maintenance. However, when consumed in megadose amounts, concerns regarding its impact on kidney health have been raised. In particular, the association between high-dose vitamin C intake and the risk of kidney stones has been widely discussed in various studies. This article will examine the effects of vitamin C megadoses on kidney health based on scientific research and provide guidelines for safe consumption. 1. Vitamin C Megadose and Kidney Stone Risk (1) Oxalate Accumulation When metabolized in the body, vitamin C converts into oxalate, a substance that can bind with calcium in the kidneys and form calcium oxalate stones. Research Findings: Studies indicate that high-dose vitamin C intake increases oxalate levels in the urine, which may elevate the risk of kidney stones. A large-scale study found that men who consumed over 1,000 mg of vitamin C daily had m...